The Office of Mission and Ministry is charged with ensuring that Seton Hall fulfills its Catholic mission. The office oversees eleven initiatives, works to infuse Catholic values, faith and intellectual heritage throughout the University and helps promote the University's efforts at developing servant leaders.

The name of the Office of Mission and Ministry echoes the language of the Bible. The word “mission” comes from the Latin word for “sending.” In the Bible many persons are “sent” by God to accomplish particular tasks on His behalf, but Jesus especially is sent, as He said, “I came from God and am here; I did not come on my own, but he sent me” (John 8:42b). The word “ministry” derives from the Latin word for “service.” In the Bible also many persons serve at the behest of God, but especially Jesus who said about Himself, “The Son of Man came not to be served, but to serve” (Mark 10:45b).